Transfer RNA modifications: nature's combinatorial chemistry playground

Phase-transfer dynamic combinatorial chemistry.

A two-phase approach to dynamic combinatorial chemistry is described using disulfide exchange chemistry; the use of two phases significantly increases the possibilities and the scope of dynamic combinatorial chemistry by facilitating the combination of otherwise incompatible building blocks.

Combinatorial chemistry

Combinatorial chemistry, which did not even exist fifteen years ago, is a new subfield of chemistry that is starting to provide insights into molecular interactions, biochemical catalysis and drug development. Instead of finding and testing naturally existing compounds for useful activity, the basic aim of combinatorial chemistry studies is to create vast numbers of new, synthetic compounds and...

Combinatorial chemistry.

Transfer RNA modifications and synthesis in animal cells.

and tumors is presented. Such differences have been observed in the early stages of sea urchin development and between tumors and their tissues of origin. In particular, the meaning of differences found between tRNA from Morris hepatomas and normal rat liver is discussed. Evidence is presented that tRNA synthesis in mammaliam cells proceeds via a short-lived precursor state and that the finishe...

Concepts of Combinatorial Chemistry and Combinatorial Technologies

Combinatorial Chemistry and Combinatorial Technology (CC/CT) are a new interdisciplinary field joining computerassisted combinatorial chemistry with automated parallel synthesis of chemical ìlibrariesî followed by automated screening. The main purpose of computer assisted combinatorial chemistry is to generate thousands structurally diverse compounds as libraries, maximising their diversity, wh...